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KMID : 0368019890120030211
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Journal of Soonchunhyang University
1989 Volume.12 No. 3 p.211 ~ p.214
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Change of blood group antigens and sugar chain antigen associated with cancer
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이순곤/Lee, S.G.
이임순/조태호/유훈/Lee ,L.S./Cho, T.H./Yoo,H.
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Abstract
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The blood group antigens of the ABO system occur not only on erythrocytes but alse in many other tissues: e.g., mucus of the digestiive tract and the respiratory tract contains large amounts of those antigens. Their antigenic determinants are composed of carbohydrate moieties and carried on glycoproteins of mucin and on glycolipids of cell membrance.
Changes in the expression of blood group antigens A,B, and H(the antigen that defines blood group type) are known to occur in cancer tissues. The most common change is a loss or diminution of antigens A and B. This phenomenon is probably due to the incomplete biosynthesis of these antigens, which is associated with accumulation of precursor antigens.
Currently, the chemical structure of antigenic determinants recognized by monoclonal antibodies against cancer cells is being studied extensively, and some of them were discovered to be carbohydrate moieties. In addition, a monoclonal antibody raised against a coion cancer cell line was shown to recognize sialylated Lewis^(a) antigen, a modified blood group antigen.
While further studies may be required to eliminate completely the less likely possibility that the phenomena observed can be explained by intracellular exoglycosidases, these findings strongly suggest that incomplete or abnormal synthesis of carbohydrates including group antigens due to decreased or abnormal expression of glycosyl transferases contributes to the formation of some tumor-associated antigens.
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